Sanes receives Gruber Neuroscience Prize

first_imgJoshua R. Sanes, the Jeff C. Tarr Professor of Molecular and Cellular Biology and founding director of the Center for Brain Science, has been named the recipient of the 2017 Gruber Neuroscience Prize.The award, which includes a $500,000 prize, recognizes Sanes’ groundbreaking work to understand the mechanisms and molecules that drive the formation and specificity of neural connections, known as synapses, within the nervous system.In addition to opening avenues for studying the brain, Sanes’ work spurred the development of new ideas about how the brain processes information and the development of new tools and technologies marking and manipulating neurons and the synapses they form.Created through an agreement between Yale University and the Peter and Patricia Gruber Foundation, the prizes are awarded to individuals in cosmology, genetics, and neuroscience whose groundbreaking work provides new models that inspire and enable fundamental shifts in knowledge and culture.Sanes will receive the award at the 47th annual meeting of the Society for Neuroscience in November.“Through his elegant and groundbreaking work, Josh Sanes has altered our understanding of how synapses, the communications junctions between neurons, are formed,” said Robert Wurtz, a National Institutes of Health distinguished investigator and chair of the prize’s selection advisory board. “The significance of his work has been profound, for synapses play a critical role in every aspect of brain function, including learning, reasoning, and memory.”“It’s an incredible honor to receive this recognition,” said Sanes. “I’m not at all sure I deserve it, but I’m extremely flattered, especially because it represents the judgment of eminent neuroscientists whom I’ve admired for many years.”Although Sanes’ work has used state-of-the art molecular and genetic tools, his introduction to neuroscience developed from a fascination with psychology, particularly with mental illness. While still in high school, he began working in the lab of microbiologist Robert Guthrie, who was then developing what would eventually become the first successful blood test for phenylketonuria, a genetic disorder that leads to mental retardation.“It was the kind of repetitive work that high school kids could do,” Sanes said. “It wasn’t super high-tech or super expensive equipment, but you were still making a contribution. [And] I really came to love working in labs.”As an undergraduate at Yale, Sanes worked in the lab of Paul Greengard, whom he credits for introducing him to “big-time, high-class neurobiology.” Later, as a graduate student at Harvard, Sanes had hoped to explore the biological foundations for mental illness, but current technology wasn’t able to address such questions, so he began working on synapses, which are thought to malfunction in some behavioral disorders.After finishing his doctorate in 1976, Sanes spent a year working on Capitol Hill in the Office of Technology Assessment, where he advised members of Congress on scientific and technical issues, before beginning his postdoctoral work, first at Harvard with neurobiologist U.J. “Jack” McMahan and then with neuroscientist Zach Hall at the University of California, San Francisco.In McMahan’s lab, Sanes demonstrated for the first time that some of the signals used to organize the synapse were contained in the extracellular matrix that surrounds muscle fiber. In Hall’s lab, Sanes began to describe the biochemical composition of a thin layer of that matrix known as the basal lamina.Sanes then moved on to a faculty position in the department of physiology at the Washington University School of Medicine, where he worked to identify and characterize molecular factors within the extracellular matrix that help direct the formation of the neuromuscular junction, including laminin beta-2, agrin, and fibroblast growth factors.Later, working with another then-Washington University colleague, Jeff Lichtman, Sanes began generating — with the aid of fluorescent proteins — a technique for tagging mice with color-coded neurons. The resulting images from these “Brainbow” lines have been used in labs around the world to identify specific neural pathways within the brain’s complex tangle of neurons.In 2004, Sanes returned to Harvard, where he helped found the Center for Brain Science, where his work was dedicated to the analysis of synaptic specificity in retina neurons, examining how neurons choose partners with which to form synapses. Sanes’ lab has identified and described many of the molecules that promote specificity within the retina, such as sidekicks and cadherins. These findings have transformed how scientists understand the functional architecture of the central nervous system.last_img read more

Fourth vCJD case linked with blood transfusion in UK

first_img Variant CJD is the human counterpart of bovine spongiform encephalopathy, or mad cow disease, which spread through British cattle herds in the 1980s and 1990s. Most vCJD patients are believed to have acquired the fatal brain disease by eating beef from diseased cattle. See also: The United Kingdom uses a number of precautions to protect the blood supply from vCJD infectivity, the HPA noted. Since 1997, new cases of vCJD have triggered a search for and destruction of any blood donated by the case-patient. Since 1998 the United Kingdom has used blood plasma from the United States to produce all plasma derivatives. And since October 1999, white blood cells, which may pose the greatest risk of transmitting vCJD, have been removed from blood used for transfusions. Jan 18 UK HPA news release Jan 22, 2007 (CIDRAP News) – Health officials in the United Kingdom have found a probable fourth case of variant Creutzfeldt-Jakob disease (vCJD) associated with a blood transfusion from someone who unknowingly had the disease. Authorities have classified the new case as probable, since vCJD cannot be definitively diagnosed until after death. Postmortem studies have been done on 112 of the 158 vCJD case-patients who have died, and have confirmed the disease in all cases, the HPA said. The case was diagnosed in a patient who received blood 9 years ago from a person who later was found to have vCJD, the UK Health Protection Agency (HPA) said in a Jan 18 statement. All 23 people have previously been informed of their potential exposure to the disease and advised to take precautions to reduce the risk of passing it to others via healthcare procedures, such as surgery, the statement said. “A transfusion from the same blood donor was also associated with one of the previously identified cases,” the HPA said. “The patient is still alive and is under specialist care.” “This new case of vCJD infection increases our concern about the risk to the small group of people who had blood transfusions from donors who unknowingly at the time of donation must have had vCJD infection,” Peter Borrielo, director of the HPA Centre for Infections, said in the news release. “However, this new case does not change our understanding of the risk for other people in any specific way.” The first case of vCJD associated with a blood transfusion was found in December 2003. So far, authorities have identified 66 people in the United Kingdom who have received “vCJD-implicated” transfusions, of whom 40 have died of causes other than vCJD, the HPA said. Twenty-three people are alive and have not been diagnosed with vCJD. Jul 22, 2004, CIDRAP News story “Another UK patient may have caught vCJD from blood” Sep 24, 2004, CIDRAP News story “UK tells blood-product recipients about possible vCJD risk”last_img read more

Increased number of airlines to Split and Brac

first_imgGreat announcements come to us from airports in Croatia, which this year never have more scheduled flights.In 2018, between March 25 and October 27, it was introduced more than 70 new regular lines, while the growth of the total number of rotations is 15% compared to 2017. This growth represents an increase in the number of rotations from 29.843 rotations in 2017 to more than 34.400 rotations in 2018. And that this season will be a record again, or at least on the right track, is shown by the data as they are in February 2018 Croatian airports recorded 229 thousand passengers or 13,9% more than in the same month last year, according to data from the Central Bureau of Statistics (CBS).Analyzing the summer flight schedule by destination, according to the absolute number of announced new rotations, Split leads with an increase of 27,7%, in second place is Dubrovnik with an increase of 19,6%, while in third place is Zagreb with a growth of 6%. This year, in addition to numerous multi-year flights from European cities, Split Airport will be connected by new Volote flights with Nice, Palermo and Bergamo, while Thomas Cook flights will connect it with London, Bristol and Glasgow, Dausseldorf and Hanover. , so this year Split will have almost 90 direct lines with Europe.A year after the new extended runway of Brac Airport was put into operation, this year it is planned that twice as many passengers will land on it as last year. Thus, with 47 airline guests as expected on the basis of already signed contracts and flight announcements, Brac would have the best year in the history of the airport. “86-seater Dash planes will fly from Zagreb, and the Adria Airways route from Ljubljana to Brač will be introduced for the first time in May. flights via Ljubljana to Brac directly from Paris, Brussels and Amsterdam ” said is Tonči Peović, director of Brač Airport.From this summer, it will be possible to fly to Brac for the first time from Bern, Switzerland, by Skyworks, which will fly a 60-seat plane on Saturdays from June, just as Luxembourg will be connected to Brac every week. TUI is strengthening all its lines to Brač, so it flies from Brussels, Rotterdam and Deauville, and in the peak season, two-week lines to Brač from Italy are expected.Related news:MORE THAN 70 NEW REGULAR AIRLINES INTRODUCED FROM MARCH TO END OF OCTOBERPASSENGER GROWTH IN AIRPORTS OF 14% ACHIEVED IN FEBRUARYIS THE RIJEKA-KÖLN AIRLINE THREATENED THROUGH POOR FULLNESS?</p>
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Wilfried Zaha posts cryptic tweet after Arsenal’s £40m transfer bid is rejected

first_img Top articles Full Screen Read More SPONSORED Arsenal’s opening bid of £40m for Wilfried Zaha was turned down by Crystal Palace (Picture: Getty)Wilfried Zaha has got Arsenal fans talking with a cryptic tweet amid speculation that he could be set for a move to the Emirates this summer.Arsenal have had a bid of £40million rejected for Zaha, with Crystal Palace holding out for a fee of around £70m for the 26-year-old forward.Unai Emery has a tight transfer budget following the Gunners’ failure to secure Champions League qualification, but they have not given up hope of signing Zaha just yet.While Palace were reportedly left ‘furious’ and ‘incensed’ by the opening offer, Arsenal are already lining up their next move to lure Zaha from south to north London..AdvertisementAdvertisementADVERTISEMENT 1/1 Coming Next Video Settings Ian Wright is confident Zaha would be a ‘magnificent’ signing for his former club this summer.‘We’re trying to get Wilfried Zaha, which would be magnificent,’ Wright told The South China Morning Post.‘You want competition for places. Defensively, I think everyone can agree, we need some strength in there.More: FootballBruno Fernandes responds to Man Utd bust-up rumours with Ole Gunnar SolskjaerNew Manchester United signing Facundo Pellistri responds to Edinson Cavani praiseArsenal flop Denis Suarez delivers verdict on Thomas Partey and Lucas Torreira moves‘You can always strengthen in the midfield. Aaron Ramsey’s gone.‘We need that midfielder who is going to join the front guys and try to contribute with goals.‘Goals is a premium so you always want to be linked with a striker that might be able to come and help.’MORE: PSG want Arsenal target Malcom as part of deal to send Neymar back to Barcelona Read More Advertisement PLAY Read More It’s no secret that Zaha grew up supporting Arsenal and his brother, Judicael, has pleaded with Palace to let the attacker seal his ‘dream’ transfer.More: FootballRio Ferdinand urges Ole Gunnar Solskjaer to drop Manchester United starChelsea defender Fikayo Tomori reveals why he made U-turn over transfer deadline day moveMikel Arteta rates Thomas Partey’s chances of making his Arsenal debut vs Man CityIn a tweet on Saturday, Zaha appeared upset with the constant speculation of people speaking for and about him – but it’s not clear who specifically the message was aimed at.‘Whatever happened to speaking facts?’ the Ivory Coast international told his followers.‘Its sad and annoying how anyone will just open their mouth and speak on things or situations they know absolutely nothing about.’ Skip Rio Ferdinand tells Ole Gunnar Solskjaer to drop struggling center_img Visit Advertiser website GO TO PAGE Advertisement Skip Ad About Connatix V67539 Zaha is currently on international duty with the Ivory Coast at the 2019 Africa Cup of Nations and scored in the side’s 4-1 victory over Namibia on Monday.Speaking ahead of the Ivory Coast’s last-16 clash with Mali, Zaha refused to rule out a move to Arsenal in the coming weeks.Asked about Arsenal’s failed £40m offer, Zaha told On Sport: ‘I have no comment on it. The only thing that’s on my mind right now is trying to win this cup [AFCON].’Pushed on whether he would like to play for Arsenal, he replied: ‘I don’t know… we’ll see in the future.’ 1 min. story / by Metro Read More Metro Sport ReporterSaturday 6 Jul 2019 4:49 pmShare this article via facebookShare this article via twitterShare this article via messengerShare this with Share this article via emailShare this article via flipboardCopy link782Shares Read More Manchester United captain Harry Maguire Comment Wilfried Zaha posts cryptic tweet after Arsenal’s £40m transfer bid is rejectedlast_img read more

O’Shea Esplanade home at Machans Beach a beachside delight

first_img145 O’Shea Esplanade, MACHANS BEACH. For Sale by Marsh Property.A SHIFT to cooler climes has provided an opportunity to own a slice of paradise at Machans Beach.Graham Burridge and Melissa Lovejoy have made the bright and airy waterfront beach house at 145 O’Shea Esplanade their home for the past nine years.After 25 years in Australia’s north they now have plans to retire to Tasmania and run a luxury AirBnB.The couple had their eye on the three-bedroom, two-bathroom house two years before they bought it.“We’d lived in another street in Machans and fell in love with whole community spirit and fact here’s no high-rises and no tourism as such so it stays quiet,” Mr Burridge said.“We fell in love with it when we moved into Machans but couldn’t afford it. “We walked by it all the time looking at it with jealousy I suppose.“My wife said to me that some day it would come on the market and we will be able to afford it and sure enough it did.” Extensive renovations converted the tiny front deck and bedroom into a sprawling veranda taking in the vast expanses of the Coral Sea, rejuvenated the kitchen and added a third bedroom.Mr Burridge said renovations were completed in February this year by local tradespeople.More from newsCairns home ticks popular internet search terms3 days agoTen auction results from ‘active’ weekend in Cairns3 days ago“The location is brilliant. You’re far enough from the ocean you don’t get too much splash in storms or cyclones but you are close enough to just walk on over the road to the water,” Mr Burridge said. “The front is where you want to be. We’ve had many dinner parties sitting on the front deck watching the lights of ships going by out at sea.“When we renovated we made sure the front rail was just high enough to lean against with a cold drink and a bowl of peanuts, looking at the view.”On the rare occasion the weather turns bad, a deck out the back near the pool can fit up to 20 people around a sizzling barbecue.Marsh Property sales agent Chris Marsh said the idyllic location would suit couples or families with small children or teenagers. “A bedroom downstairs with an ensuite can be accessed across an indoor pond via a timber walkway and offers separate external ground- level access,” he said.“This area offers flexible options for grandparents, teenagers or AirBnB visitors.”A huge master bedroom with walk-through robe and a generous downstairs lounge area have also been cleverly renovated and redesigned to retain the original cottage feel.“But there has been little compromise on modern creativity and it will provide everything a buyer is looking for,” Mr Marsh said.“The home is also air conditioned, features a dedicated study, established tropical gardens and a large chook pen.“Be prepared to fall in love with one of our favourite properties ever.”last_img read more

Grand Gold Coast home an entertainer’s dream

first_imgIt has an open floorplan. What an entrance. The grand entrance makes an immediate impression with its soaring ceilings, trendy pendant lighting and a glimpse of the lounge room with a temperature censored gas fireplace and stacked stone feature wall.The main living area with a central kitchen is smartly positioned to make the most of the water vistas. MORE NEWS: Another eye-watering sale notched on Gold Coast’s ‘Millionaires’ Row’ 22 Karema Cres, Runaway Bay, has hit the market offering entertainers the perfect spot to host soirees. Enjoy life on the water’s edge at this Runaway Bay home which offers grand proportions and stylish interiors. The four-bedroom house at 22 Karema Cres has plenty of wow factor. Not a bad sight. More from news02:37International architect Desmond Brooks selling luxury beach villa12 hours ago02:37Gold Coast property: Sovereign Islands mega mansion hits market with $16m price tag2 days ago Plenty of room for guests to enjoy the views. The contemporary kitchen serves up stone benchtops, Smeg appliances, a Zip tap, breakfast bar and servery window to the outdoor entertainment area. The covered alfresco area has views over the in-ground pool with glass fencing. center_img MORE NEWS: Gold Coast home charms house hunters with its character The dreamy main bedroom. The main bedroom occupies the whole second level and has a private balcony, spacious retreat, walk-in wardrobe and a deluxe ensuite with dual vanities, a free standing bath and rain shower.The remaining three bedrooms are on the ground floor with double built-in wardrobes. There’s also a study and a wine cellar with LED lighting under the staircase. The contemporary kitchen. The wine cellar is under the stairs. Harcourts Coastal Broadbeach agent Andrew Harvey, who is marketing the property with Michael Harvey, said the home was made for entertaining. “Is an absolute entertainer’s paradise in a superb location,” Mr Harvey said. “You would be hard pressed to find a renovated property anywhere that has been shown the same degree of attention and detail. “The result is simply outstanding.”The property has a price guide above $1.75 million.last_img read more

“Hillary’s Law” Campaign Launched to Change Parental Notification Laws

first_img“Hillary’s Law” Media Release 3 June 2015A campaign has been launched seeking changes to the parental notification law when a teenage daughter becomes pregnant.Dubbed “Hillary’s Law”, it is based on my experience as a mum which no other parent should have to experience. My 15 year old daughter was sneaked off for an abortion by the community health nurse and with the permission of the school. I was never informed. Our daughter changed after that event and our life as a family was turned upside down. She subsequently tried to take her own life. It was then that our daughter told us why the health nurse had brought her home a year ago. The nurse had not taken her to a counselling appointment; instead she picked our daughter up from school and took her to an abortion clinic.Society, the law and government agencies expect parents to take responsibilities for the behaviours of their children. We do this across government agencies such as health, education, welfare, and justice, yet when it comes to abortion, parents can be locked out of the process and still be left to clean up the mess left behind. Frequently they only get to hear of the procedure when they are dealing with a distraught child who is displaying psychological trauma and acting out in anti-social behaviours such as self-harm or abusive and disorderly or criminal behaviours.My experience is not the only one of its kind that has happened. I am being contacted by more and more families who have experienced similar circumstances.The petition asks for Parliament to pass legislation that allows for a parent of a girl under the age of 16 years to be informed if she has a pregnancy confirmed and before she is referred for any resulting medical procedure; and that the young girl be fully informed as to procedure, possible repercussions and after-effects before any medical procedure is undertaken.A petition has been presented to Parliament by Wanganui MP Chester Borrows and will be considered by the Justice and Electoral Select Committee.The website is read more

New United Mexican States Ambassador to Dominica

first_img 47 Views   no discussions Share Sharing is caring! Share LocalNews New United Mexican States Ambassador to Dominica by: – June 28, 2012center_img Ambassador Edmundo Font Lopez presenting his credentials to President Liverpool The new Ambassador of the United Mexican States to Dominica His Excellency Edmundo Font Lopez described future predictions for relations between his country and Dominica as a splendid and prosperous one.H.E. Edmundo Font Lopez replaces previous ambassador to Dominica, Gerardo Lozano.The new ambassador presented his letter of credence with wishes of success and a beneficial alliance to Dominica’s President H.E. Nicholas Liverpool on Wednesday.“We have always had excellent relations and good friendship. As a country belonging to the great Caribbean, Mexico has one of its priorities to achieve a greater bond with the region and President Calderon has highlighted on many occasions the importance of Mexico to strengthen its ties with the English speaking countries, particularly with members of the Organization of Eastern Caribbean States (OECS) with whom we share similar goals and challenges. As President Calderon mentioned during the second Caricom/Mexico Summit, the cooperation for development is one of the main challenges we face. For that reason I totally agree that we must promote the exchange of experiences in these areas to increase the competitiveness of our economies and to provide employment to our people. We can collaborate and share experiences in areas such as tourism, trade facilitation and transportation and for modernisation.”H.E. Dr. Nicholas Liverpool received the new ambassador with anticipation of stronger mutual cooperation between the two countries.“Your Excellency, I note your commitment to continue and deepen the work of your predecessors in maintaining and strengthening the bonds of friendship and cooperation which already exists between our countries. We look forward to the strengthening of mutual cooperation in areas of common interest and to even closer ties as we continue in our search for a brighter future for us all.”“Dominica will make every effort to explore avenues of increased cooperation between our two countries. Our cooperation with your country in the regional and international arena can be counted upon and we look forward to providing continual support for the candidacy of the Mexican United States on various regional and international bodies in appropriate circumstances.”H.E. Lopez shared his country’s intention to help develop the island by continuing to provide scholarships for Dominicans.“My mission will be to increase the cultural programme in our two countries and to have more people of the Commonwealth of Dominica benefiting of the scholarships that the Mexican Government offers in order for the students to return and make a vibrant contribution in their country upon their return.”Government Information Service Share Tweetlast_img read more

‘No-one can predict Messi’s future’

first_img Loading… “My dream, if I have to be honest, is to see him wearing the Newell’s Old Boys shirt.” Biancucchi was then asked if Paulo Dybala or Lautaro Martinez could take the baton from their esteemed compatriot for Argentina. “This is a great unknown. Argentina has some great young talents, but there will be no other phenomenon like Leo. read also:Video: Iranian child offers himself to Barcelona as ‘new’ Messi “I really like Dybala and Lautaro is growing exponentially. I hope they play at high levels for a long time. “Having said that, I believe Messi’s heir isn’t born yet.” FacebookTwitterWhatsAppEmail分享 Lionel Messi’s cousin, Massimo Moratti, has confessed that he would ‘love’ to see the forward leave Barcelona but warned ‘no-one else knows’ his future. Messi sends message of support to healthcare workers Moratti tried to take Messi to Inter when he was President and is currently leading the calls for him to join the Nerazzurri, and Maxi Biancucchi appeared to endorse the move, even if he ‘couldn’t see’ it happening. “The truth is that this is something very personal, no-one else knows,” he told FootballNews24. “Personally, I would love to see him play for another team, as many of his fans would like, to prove to those who claim that Messi is only good for Barcelona that they are wrong. The truth is that genes like his can play well anywhere. “Honestly, I don’t see him in Italy. Any opinion of mine will arouse suspicion but, like I said before, the decision is his alone.Advertisementcenter_img Promoted ContentFantastic-Looking (and Probably Delicious) Bread ArtWho Earns More Than Ronaldo?Best & Worst Celebrity Endorsed Games Ever MadeWho Is The Most Powerful Woman On Earth?A Soviet Shot Put Thrower’s Record Hasn’t Been Beaten To This DayCouples Who Celebrated Their Union In A Unique, Unforgettable Way8 Fascinating Facts About CoffeeThe Models Of Paintings Whom The Artists Were Madly In Love WithBirds Enjoy Living In A Gallery Space Created For ThemThe Very Last Bitcoin Will Be Mined Around 2140. Read More7 Universities In The World With The Highest Market ValueWho’s The Best Car Manufacturer Of All Time?last_img read more

De Lima says ‘drug czar’ offer meant to shame Robredo

first_img She added that Duterte wants to create the narrative of putting all the blame of his failures to someone else, instead of admitting that he lied about winning the drug war, despite killing thousands of people.  MANILA – Sen. Leila de Lima has cautioned Vice President Leni Robredo from accepting the challenge of President Rodrigo Duterte to solve the country’s illegal drug problem in six months. “The real reason why Duterte is even floating this idea of offering VP Robredo that post is because he wants to shame her and all other critics of his flawed drug war,” De Lima said. The opposition senator said in a statement that Duterte’s offer to Robredo to lead the government’s narcotics crackdown is just a “silly trap” that aims at shaming the Vice President (VP). “If it can, why didn’t he create such a post on his first days as President? Why create one now for VP Robredo?” De Lima said. “I compare it with the silly traps that Tom lays down for Jerry as he hides around the corner, hoping that Jerry would be dumb enough to jump on such an obvious ploy that any 3-year-old can figure out.”/PNcenter_img Robredo was offered by Duterte to be the administration’s “drug czar” for six months after the Vice President repeatedly branded the administration’s anti-drug campaign as a “failure.” Presidential Spokesperson Salvador Panelo said that Robredo would be given a cabinet secretary portfolio and would be in charge of all agencies involved in the implementation of anti-illegal drug laws under her command, should she take Duterte’s offer. De Lima, however, said that the ploy of Duterte and Panelo was to put Robredo in a bad light as the two knew the drug czar post wouldn’t be effective “winning his drug war brand.”last_img read more